Brain stimulation and brain scans for hard-to-treat depression
Part of Mental health clinical trials.
This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 20 and 65 years old
- Have moderate to severe depression (or persistent depressive disorder) with specific depression rating test results (HRSD-17 score 18 or higher)
- If your depression is hard to treat, you have tried many depression treatments without enough improvement (including multiple antidepressants, at least one psychotherapy, and certain other options like ketamine/esketamine or ECT or rTMS)
- Be able to have an MRI brain scan (no MRI safety issues) and have no major medical or psychiatric condition that would make depression not the main issue
- Agree to skip if you have a history of psychosis, seizure disorder, active neurological disease, pregnancy, or substance dependence in the last 6 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
This trial tests a magnetic brain stimulation treatment that you can do at home, for moderate to severe depression. It aims to see if this therapy can improve your symptoms without requiring frequent hospital visits.
This study uses brain imaging to guide a noninvasive treatment called transcranial magnetic stimulation (TMS) for people with depression. It aims to see if tailoring the stimulation to each person's brain can improve symptoms.
This study looks at changes in depression “markers” to understand what treatments help and why. You’ll have non-invasive brain stimulation and scans before and after treatment, over about 8 weeks.
This study tests a new type of magnetic brain stimulation (called theta burst stimulation) for people whose depression hasn't improved with standard treatments. It aims to see if this treatment is safe and effective for both adults and teenagers with moderate to severe depression.
This study looks at brain wave patterns in people with depression who are receiving a type of brain stimulation called rTMS. It aims to understand how the brain changes during recovery, which may help improve future treatments.
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.