Neoadjuvant chemo plus targeted treatment for high-risk retroperitoneal sarcoma
Part of Cancer clinical trials.
This trial tests giving chemotherapy together with a targeted treatment before surgery for people with a high-risk retroperitoneal sarcoma. The goal is to shrink or control the tumor so surgery can potentially remove it with minimal remaining disease (R0/R1).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed high-risk retroperitoneal sarcoma (DDLPS, LMS, UPS, or high-risk SFT).
- Your tumor has not had surgery beyond biopsy, and you have not had chemo, radiation, or targeted therapy yet.
- There is no history of another cancer (second malignancy) and no confirmed or highly suspected spread to other organs.
- You have specific tumor subtype details: DDLPS needs special marker tests; LMS needs tumor size 10 cm or larger; UPS includes all grades; SFT must be high-risk by a specific score.
- Your doctor believes surgery can achieve R0/R1 removal, and your overall health is good enough for chemo and surgery.
- You can understand the consent form and agree to participate; you cannot be pregnant or breastfeeding, and pregnancy prevention is required if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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