Clin2
NCT05857358Possibly a fitNot yet recruiting

Fat cell therapy for dry mouth in autoimmune disease

Xerostomia

Part of Mouth & dental clinical trials.

This trial is testing a new treatment for severe dry mouth caused by autoimmune diseases like Sjögren's syndrome. The treatment uses a special type of fat-derived cells, which may help repair the glands that produce saliva, potentially reducing dry mouth symptoms and improving quality of life.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
18 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You must be between 18 and 65 years old.
  • You need to have been diagnosed with Gougerot-Sjögren disease or a related autoimmune condition causing dry mouth.
  • Your dry mouth symptoms should be significant, based on a standard questionnaire score of at least 30 out of 60.
  • You cannot be a heavy smoker (more than 5 cigarettes a day).
  • You must not have any active infections or bleeding disorders, and you should not be taking blood thinners.
  • You cannot be pregnant or breastfeeding, and if you can get pregnant, you must use effective birth control.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07838454Not yet recruiting· Phase 2
Stem cell treatment for dry mouth in sjögren syndrome

This trial tests a new treatment using stem cells and exosomes (tiny healing particles) injected into the salivary glands under the jaw. It aims to improve saliva production and relieve dry mouth in people with primary Sjögren syndrome.

Istanbul, Kadikoy
NCT06392711Recruiting· Phase 1
Stem cell therapy for dry mouth not from radiation

This trial tests a new treatment using special cells (mesenchymal stromal cells) from your own bone marrow to help with dry mouth that is not caused by radiation. The goal is to see if it can increase saliva production and improve quality of life.

Madison, Wisconsin
NCT07594184Recruiting
Can hyaluronic acid injections help dry mouth?

This study tests whether injections of hyaluronic acid—a naturally occurring substance—can relieve chronic dry mouth (xerostomia). If it works, it could offer a new treatment option for people who have had dry mouth for at least a year.

Barcelona, Barcelona
NCT05106608Recruiting
Mobile plus light therapy for dry mouth after head and neck cancer

This study tests whether “photobiomodulation” light therapy, guided by a phone app, can improve chronic dry mouth (xerostomia) in people who finished radiation for head and neck cancer. It may help reduce bothersome mouth dryness and support better day-to-day comfort after treatment.

Granada
NCT06805448Recruiting· Phase 1/Phase 2
Stem cell treatment for dry mouth in Sjögren's disease

This trial tests if injecting fat-derived stem cells into the salivary glands can help relieve dry mouth in people with Sjögren's disease. It aims to improve saliva flow and reduce discomfort.

Copenhagen
NCT07290946Not yet recruiting· Phase 2
Stem cell therapy for dry mouth after head and neck radiation

This trial tests whether repeated stem cell treatments can help relieve dry mouth caused by radiation therapy for head and neck cancer. The goal is to improve saliva production and quality of life for cancer survivors.

Hear when a new Xerostomia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.