Clinical trials
Xerostomia clinical trials
Below are recruiting xerostomia clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04392622RecruitingPhase 1
Limonene gelcaps with radiation and chemo to prevent dry mouth
This Phase 1 study tests whether a citrus-flavored supplement (d-limonene gelcaps) can help prevent or reduce dry mouth (xerostomia) in people getting radiation plus chemotherapy for certain head and neck cancers. It aims to see how well the approach is tolerated and whether it can protect saliva function during treatment.
Stanford, CaliforniaAges 18 years+ - NCT06282497Recruiting
New radiation technique to reduce dry mouth in nasopharyngeal cancer
This trial compares a new radiation technique designed to reduce dry mouth (xerostomia) with standard radiation for people with nasopharyngeal cancer. It aims to see if the new approach can protect saliva glands while still treating the cancer effectively.
Zhongshan, GuangdongAges 18–70 - NCT07476209Recruiting
Salivary gland procedure vs light therapy for dry mouth from radiation
This trial compares two treatments—a salivary gland procedure (sialendoscopy) and a light therapy (photobiomodulation)—to prevent dry mouth caused by radiation therapy for head and neck cancer. If you are about to start radiation and meet the dose limits, you may be eligible.
AlexandriaAges 18 years+ - NCT07035626RecruitingPhase 1/Phase 2
Spermidine to prevent dry mouth from radiation therapy
This trial tests whether spermidine (a natural compound) can help prevent dry mouth caused by radiation treatment for head and neck cancer. It is for patients who will receive a significant dose of radiation to their saliva glands.
Chengdu, SichuanAges 18–80 - NCT06287294Recruiting
Taste problems and dry mouth in advanced cancer
This study looks at taste problems in people with advanced cancer who also have a dry mouth. It aims to understand the link between dry mouth and taste changes to help improve symptom management.
DublinAges 18 years+ - NCT06392711RecruitingPhase 1
Stem cell therapy for dry mouth not from radiation
This trial tests a new treatment using special cells (mesenchymal stromal cells) from your own bone marrow to help with dry mouth that is not caused by radiation. The goal is to see if it can increase saliva production and improve quality of life.
Madison, WisconsinAges 18–90 - NCT06465628Recruiting
Acupressure for dry mouth after head and neck cancer treatment
This trial tests if acupressure can help with dry mouth caused by radiation therapy for head and neck cancer. If you have dry mouth after treatment and can speak Cantonese or Mandarin, you may be able to join.
Hong Kong, Hong KongAges 18 years+ - NCT06714253RecruitingPhase 1/Phase 2
Circular RNA treatment for dry mouth after radiation
This trial tests a new type of treatment called circular RNA to see if it can help people with long-term dry mouth after radiation for head and neck cancer. It's for patients whose dry mouth hasn't gone away with other treatments.
Iowa City, IowaAges 18 years+ - NCT06984848Recruiting
Mouth spray for dry mouth in older adults
This trial tests an enzyme-containing mouth spray (Oral7®) to see if it helps with dry mouth, improves saliva flow, and boosts quality of life for older adults. If you often have a dry mouth, this spray might offer relief.
Kubang Kerian, KelantanAges 60 years+ - NCT06544798Enrolling by invitationPhase 2
Long-term follow-up of gene therapy for dry mouth
This study follows patients who previously received gene therapy for dry mouth caused by radiation. It aims to track long-term safety and any lasting benefits.
Gilbert, ArizonaAges 18 years+ - NCT07425275Recruiting
Study of a mouth care plan for dry mouth in diabetes
This trial tests a special mouth care plan to help people with diabetes who have dry mouth. The goal is to see if it improves comfort and mouth health.
Peshawar, KPKAges Up to 18 years - NCT07251543Enrolling by invitation
Salivary gland massage for dry mouth in older adults
This study tests whether a simple salivary gland massage program can help older adults with dry mouth improve chewing, swallowing, and overall oral health. It's designed for people aged 65 and older who can follow instructions and participate in activities.
Chiayi City, TaiwanAges 65 years+ - NCT07711626Recruiting
Foot massage and ear stimulation for head and neck cancer symptoms
This study tests whether foot massage (reflexology) and a mild nerve-stimulation device on the ear can help reduce side effects during chemotherapy and radiation for head and neck cancer.
Hualien CityAges 30–75 - NCT04805528Recruiting
Electrical stimulation to reduce dry mouth after head-neck radiation
This trial tests a non-invasive, acupuncture-like electrical stimulation treatment (ALTENS) to help reduce dry mouth after radiation for head and neck cancers. You may qualify if you have bothersome dry mouth and had significant head-neck radiation, with no signs of active cancer and if you can come for treatments over 12 weeks.
Rochester, New YorkAges 18 years+ - NCT05106608Recruiting
Mobile plus light therapy for dry mouth after head and neck cancer
This study tests whether “photobiomodulation” light therapy, guided by a phone app, can improve chronic dry mouth (xerostomia) in people who finished radiation for head and neck cancer. It may help reduce bothersome mouth dryness and support better day-to-day comfort after treatment.
Granada, GranadaAges 18 years+ - NCT06700863Recruiting
Finding biomarkers for head and neck cancer radiation therapy
This study is looking for proteins or other substances in the blood (biomarkers) that can help predict how well head and neck cancer patients respond to radiation therapy. If you have head and neck cancer and are scheduled for radiation, possibly with chemo, immunotherapy, or targeted therapy, you may be able to join.
Nanjing, JiangsuAges 18–70 - NCT06805448RecruitingPhase 1/Phase 2
Stem cell treatment for dry mouth in Sjögren's disease
This trial tests if injecting fat-derived stem cells into the salivary glands can help relieve dry mouth in people with Sjögren's disease. It aims to improve saliva flow and reduce discomfort.
CopenhagenAges 18 years+ - NCT07170358Recruiting
Biomarker screening for head and neck cancer radiation therapy
This trial is looking for people with head and neck cancer who are about to start radiation therapy (possibly combined with other treatments). The goal is to find biomarkers that may help predict how well the treatment works or what side effects might occur.
Nanjing, JiangsuAges 18–75 - NCT07278557RecruitingPhase 2
MRI-guided radiation to reduce dry mouth from head and neck cancer treatment
This trial tests if using an MRI to map saliva glands before radiation can help spare them, reducing dry mouth. It is for people with oropharynx cancer who will receive radiation with or without chemotherapy.
Chapel Hill, North CarolinaAges 18 years+ - NCT07594184Recruiting
Can hyaluronic acid injections help dry mouth?
This study tests whether injections of hyaluronic acid—a naturally occurring substance—can relieve chronic dry mouth (xerostomia). If it works, it could offer a new treatment option for people who have had dry mouth for at least a year.
Barcelona, BarcelonaAges 18 years+ - NCT07309588Enrolling by invitationPhase 1/Phase 2
Hyaluronic acid gel for dry mouth
This trial tests if a gel made from hyaluronic acid (a natural substance that holds moisture) can help people with long-term dry mouth. It aims to make eating, speaking, and sleeping easier.
Poznan, Greater Poland VoivodeshipAges 38–78
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Common questions
- Are there clinical trials for xerostomia?
- Yes. Clin2 currently lists 21 recruiting xerostomia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a xerostomia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a xerostomia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.