Clin2
NCT06392711Worth exploringRecruiting

Stem cell therapy for dry mouth not from radiation

XerostomiaGraft-versus-host-diseaseSjogren's Disease

Part of Bones, joints & muscles, Eyes & vision, Immune system & allergy, Mouth & dental, Skin clinical trials.

This trial tests a new treatment using special cells (mesenchymal stromal cells) from your own bone marrow to help with dry mouth that is not caused by radiation. The goal is to see if it can increase saliva production and improve quality of life.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
36 people
Ages
18 years to 90 years
Study type
Interventional

Who can take part

  • You have dry mouth not caused by radiation treatment
  • You are between 18 and 90 years old
  • You have both submandibular glands (under the jaw) and they are healthy
  • You do not have salivary stones
  • Your diabetes is well-controlled (if you have diabetes)

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05857358Not yet recruiting· Phase 1/Phase 2
Cell therapy from fat tissue for autoimmune dry mouth

This Phase 1/2 study tests a new cell-based treatment made from a patient’s own fat tissue to improve autoimmune dry mouth (xerostomia). It focuses first on safety, and also looks for early signs that saliva and dry-mouth symptoms may improve.

NCT05106608Recruiting
Mobile plus light therapy for dry mouth after head and neck cancer

This study tests whether “photobiomodulation” light therapy, guided by a phone app, can improve chronic dry mouth (xerostomia) in people who finished radiation for head and neck cancer. It may help reduce bothersome mouth dryness and support better day-to-day comfort after treatment.

Granada, Granada
NCT04392622Recruiting· Phase 1
Limonene gelcaps with radiation and chemo to prevent dry mouth

This Phase 1 study tests whether a citrus-flavored supplement (d-limonene gelcaps) can help prevent or reduce dry mouth (xerostomia) in people getting radiation plus chemotherapy for certain head and neck cancers. It aims to see how well the approach is tolerated and whether it can protect saliva function during treatment.

Stanford, California
NCT05872464Not yet recruiting
Artificial saliva with cumin and ginger for dry mouth

This study tests an artificial saliva product made with cumin and ginger to see if it helps reduce dry mouth in people with head and neck cancer. It is designed for patients who are at least 6 months past radiation and have ongoing dry mouth (xerostomia).

NCT06714253Recruiting· Phase 1/Phase 2
Circular RNA treatment for dry mouth after radiation

This trial tests a new type of treatment called circular RNA to see if it can help people with long-term dry mouth after radiation for head and neck cancer. It's for patients whose dry mouth hasn't gone away with other treatments.

Iowa City, Iowa
NCT07290946Not yet recruiting· Phase 2
Stem cells for dry mouth after head and neck cancer radiation

This trial tests whether repeated injections of stem cells (mesenchymal stem cells) can help people who have chronic dry mouth after radiation therapy for head or neck cancer. The goal is to improve saliva production and reduce discomfort.

Hear when a new Xerostomia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.