Perioperative chemo plus serplulimab for specific stomach cancers
Treatments studied
Part of Cancer, Digestive system clinical trials.
This Phase 2 trial tests whether adding serplulimab (an immune medicine) to standard chemotherapy before and/or around surgery can improve outcomes for people with certain locally advanced stomach cancer. You may get serplulimab or a placebo, and researchers will compare results to see if the immune add-on helps.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18–80 and agree to participate by signing consent
- Your stomach (or stomach-area) cancer was confirmed by pathology and is pMMR but not dMMR
- Your cancer stage is T2 to T4b, with lymph-node involvement (or not) but no distant spread (M0)
- You must be well enough for treatment (ECOG performance status 0–1) and have at least 6 months to live
- Your blood, liver, kidney, and clotting test results must be within required ranges
- You must be able to provide tissue samples (biopsies and surgery) plus blood, stool, and urine samples
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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