Pioglitazone for calcium buildup in aortic valve disease
Part of Heart & circulation clinical trials.
This Phase 2 study tests whether pioglitazone can slow or improve calcific aortic valve disease. It looks for people with mild-to-moderate aortic valve narrowing and high calcium on heart imaging.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult age 35 or older.
- You have calcific aortic valve disease with mild-to-moderate narrowing on an ultrasound (echo) test.
- Your heart CT within the last month shows aortic valve calcium score of at least 200 (Agatston units).
- You can have a cardiac CT scan and agree to follow the study plan.
- Your heart pumping function (left ventricular ejection fraction) is 50% or higher.
- You do NOT have moderate/severe mitral or tricuspid valve disease, and you have no certain prior serious conditions (like prior aortic valve surgery or past pancreatitis or cancer).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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