Folic acid for slow aortic valve narrowing
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether taking folic acid (a type of vitamin B) can slow the buildup of calcium in the heart's aortic valve. It is for people with early-stage calcific aortic valve disease, and it may help prevent the condition from getting worse.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 35 years old.
- You have a condition called calcific aortic valve disease, which is when the aortic valve (the heart valve that helps blood flow to your body) becomes stiff with calcium deposits.
- Your valve narrowing must be mild to moderate — not too severe. This is checked by an ultrasound of your heart (echocardiogram) and a CT scan.
- You must not have had prior surgery on your aortic valve, or have certain other health conditions like a weak heart pumping (ejection fraction less than 50%), or moderate-to-severe problems with other heart valves.
- You must be willing to take a daily folic acid supplement or a placebo (a pill with no active ingredient) for the duration of the study, and follow the study plan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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