Vericiguat for slowing aortic valve calcium buildup
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests if the drug vericiguat can slow down the buildup of calcium in the aortic valve, which causes it to narrow and stiffen. If you have mild-to-moderate aortic valve stenosis and meet the other criteria, this study may help protect your valve from getting worse.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 35 and 79 years old.
- Your aortic valve stenosis is mild to moderate on an echocardiogram.
- A CT scan shows a certain amount of calcium buildup in your valve.
- You are not taking any medications like sildenafil or nitrates.
- You are not planning to have valve surgery or replacement soon.
- Your heart pumps blood well (LVEF 50% or higher) and you are not in advanced heart failure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether the blood pressure medication manidipine can slow or reverse calcium buildup in the heart's aortic valve. Researchers are looking for older adults with mild-to-moderate aortic valve narrowing.
This trial studies whether daily folic acid can slow or improve calcific aortic valve disease. It is for people with a mildly to moderately narrowed aortic valve plus calcium seen on a heart CT scan.
This Phase 2 study tests whether pioglitazone can slow or improve calcific aortic valve disease. It looks for people with mild-to-moderate aortic valve narrowing and high calcium on heart imaging.
This trial tests a new heart valve device (Venus-Vitae) for people with severe aortic stenosis, a condition where the heart valve is too tight. It aims to see if the device works well for patients of all surgical risk levels.
This trial studies whether lowering blood pressure affects health outcomes in people who have valve narrowing in the heart but no valve symptoms yet. It may help you understand which blood pressure targets are safest when the aortic valve is not fully opening.
This trial tests a new pill, ataciguat, to slow down the progression of moderate calcific aortic valve stenosis (a condition where your aortic valve stiffens). If you have moderate valve narrowing and meet the other criteria, participation could help find a way to delay needing surgery.
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