Peptide treatment to prevent or lessen kidney injury after heart surgery
Part of Kidney & urinary, Women’s health & pregnancy clinical trials.
This Phase 2 trial tests an LSALT peptide given around the time of “on-pump” heart surgery to help prevent or reduce acute kidney injury (a sudden drop in kidney function). It may help people who are at higher risk for kidney injury during or after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 or older and having planned non-emergency coronary and/or valve surgery using the heart-lung “on-pump” machine
- Have risk factors for kidney injury (especially kidney disease stage 2–3 plus at least one extra risk factor like older age, diabetes, hypertension, low heart pumping strength, or certain urine test results)
- Not have acute kidney injury at the time the study starts (no kidney injury already present by their kidney criteria)
- Not be having off-pump surgery, and the operation should not involve circulatory arrest or deep cooling to a very low rectal temperature
- Have no severe kidney failure (estimated kidney function below 30 or needing dialysis), no recent/ahead-of-time treatment for aortic dissection, and no current sepsis or pregnancy
- Agree to use effective birth control if you could become pregnant (and have a negative pregnancy test), and be able to give informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving amino acids during heart surgery can help protect your kidneys. It's for people at high risk of kidney injury after surgery.
This trial tests whether giving a medicine called angiotensin II during heart surgery can help prevent acute kidney injury (a sudden drop in kidney function). It is for adults having certain types of heart surgery who have a higher risk of kidney problems.
This trial is testing whether giving amino acids after heart surgery can help prevent kidney injury in children at high risk. If it works, it could offer a simple way to protect kidney function during recovery.
This trial tests if giving amino acids during heart surgery can protect the kidneys. If you are having planned heart surgery with a heart-lung machine and have reasonably good kidney function, you may be able to join.
This study tests whether a drug called R2R01 can help protect your kidneys during major heart surgery. Heart surgery can sometimes damage the kidneys, and this trial is looking to see if this new medication reduces that risk.
This trial tests whether giving L-arginine (a natural amino acid) soon after heart surgery can help protect your kidneys. It is for adults who had heart surgery with a heart-lung machine and did not have kidney problems before surgery.
Hear when a new Acute Kidney Injury trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.