Testing if angiotensin II prevents kidney injury after heart surgery
Treatments studied
Part of Heart & circulation, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether giving a medicine called angiotensin II during heart surgery can help prevent acute kidney injury (a sudden drop in kidney function). It is for adults having certain types of heart surgery who have a higher risk of kidney problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for heart surgery that uses a heart-lung machine, such as bypass surgery or valve repair.
- You are 18 years or older.
- You have a higher risk of kidney injury based on factors like low hemoglobin, high creatinine, age over 70, heart failure symptoms, or a body mass index over 30.
- You do not need dialysis or have had acute kidney injury in the last month.
- You do not have severe, untreated high blood pressure or severe lung-related high blood pressure with heart strain.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a medication called angiotensin II (brand name Giapreza) to see if it can raise blood pressure in people who have dangerously low blood pressure after heart surgery. If you or a loved one is in the hospital after heart surgery with low blood pressure that isn't getting better with standard treatments, this study may be an option.
This Phase 2 trial tests an LSALT peptide given around the time of “on-pump” heart surgery to help prevent or reduce acute kidney injury (a sudden drop in kidney function). It may help people who are at higher risk for kidney injury during or after surgery.
This trial tests if starting Angiotensin II early, instead of other blood pressure medications, can help heart surgery patients maintain safe blood pressure. It may be an option if you have low blood pressure after surgery despite receiving fluids.
This study tests a new medicine, BX-001N, to see if it can prevent kidney damage during and after heart surgery for aortic disease. It is for people with moderate kidney problems who are having planned surgery that stops the heart briefly.
This study tests whether a drug called R2R01 can help protect your kidneys during major heart surgery. Heart surgery can sometimes damage the kidneys, and this trial is looking to see if this new medication reduces that risk.
This study compares two medications given during surgery to see which one better protects the kidneys after the procedure. If you are having major non-cardiac surgery that lasts at least 2 hours and you need medication to support your blood pressure, this trial may be a good fit.
Hear when a new Cardiac Surgery trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.