Brain-targeting study of ketamine response in treatment-resistant depression
Treatments studied
Part of Mental health clinical trials.
This early-stage study looks at how parts of brain cells respond to ketamine in people with depression who have not improved with usual antidepressants. It may help researchers find why ketamine works for some people and not others, and who might benefit.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are right-handed (using the Edinburgh Handedness test).
- You are currently experiencing depression, with a screening score above 17.
- Your depression has not improved after trying one or more appropriate antidepressant medications.
- You meet criteria for major depressive disorder (MDD) based on a structured interview.
- If you’ve used ketamine before, it must have helped reduce your depression symptoms; if not, you may not qualify for this part.
- For the week before each MRI scan, you will avoid caffeine and avoid alcohol/drugs (as instructed by the team).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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