Clofarabine vs fludarabine for AML before stem cell transplant
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 2 study compares two chemotherapy medicines—clofarabine and fludarabine—given at a reduced intensity before an allogeneic stem cell transplant. It aims to see which regimen works better and is safer for people with AML who are eligible for this transplant approach.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older
- You have AML (new or secondary) that is in complete remission for transplant (marrow blast count under 5%) or MDS/LAM with marrow blast count 5% or less
- Your doctor says you can receive a reduced-intensity conditioning regimen (often based on age 60+ or medical conditions if under 60)
- You have a matched donor, and the stem cell graft will be only from peripheral blood (not cord blood)
- You are fit enough for study visits (ECOG 0 to 2) and can use effective contraception if required
- You meet key organ and infection requirements (kidney, liver, heart, and lung tests) and do not have certain excluded conditions (like promyelocytic leukemia or HIV)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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