Daridorexant for insomnia in early memory decline
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether daridorexant can improve sleep in people who have mild cognitive impairment or early Alzheimer’s disease and struggle with insomnia. It may help by improving how long and how well you sleep, with monitoring of sleep patterns and memory-related measures.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 60 and 85 years old
- Live at home (outpatient), not in a facility, and be able to attend visits for at least 2 months
- Have at least 3 months of poor sleep (at least 3 nights per week) that affects daytime life, with typical total sleep time under 6 hours
- Agree to sleep testing at the start (PSG): total sleep time under 6 hours and being awake more than 1 hour during the night
- Have early-stage diagnosis of mild cognitive impairment or mild to moderate Alzheimer’s disease and be able to do memory/neuropsych tests (MMSE 12–26, CDR 0.5–2)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is testing whether a sleep medication called lemborexant can improve sleep and reduce Alzheimer's-related proteins in healthy older adults with no memory problems. It could help find new ways to delay or prevent Alzheimer's disease.
This trial tests whether treating sleep issues and measuring sleep can help lower the risk of Alzheimer’s disease before it starts. It focuses on older adults with no dementia signs yet.
This study tests combining a CPAP machine with a sleep medication called daridorexant to treat people who have both sleep apnea and insomnia. It aims to see if this combination therapy is safe and effective for people who are just starting treatment.
This study tests whether daridorexant, a medication that helps improve sleep, can prevent Alzheimer's disease. If you have mild memory concerns but not dementia, this trial may help find out if better sleep can protect your brain.
This trial tests a new medicine, daridorexant, to see if it helps people with insomnia sleep better through the night and feel more alert during the day. The study will use a home device to check your sleep patterns before you join.
This study follows adults with insomnia who are prescribed a new sleep medication called daridorexant. It aims to see how well the medication works in a real-world setting, and to monitor its safety and effects on sleep.
Hear when a new Insomnia Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.