Daridorexant for insomnia in early memory decline
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether daridorexant can improve sleep in people who have mild cognitive impairment or early Alzheimer’s disease and struggle with insomnia. It may help by improving how long and how well you sleep, with monitoring of sleep patterns and memory-related measures.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 60 and 85 years old
- Live at home (outpatient), not in a facility, and be able to attend visits for at least 2 months
- Have at least 3 months of poor sleep (at least 3 nights per week) that affects daytime life, with typical total sleep time under 6 hours
- Agree to sleep testing at the start (PSG): total sleep time under 6 hours and being awake more than 1 hour during the night
- Have early-stage diagnosis of mild cognitive impairment or mild to moderate Alzheimer’s disease and be able to do memory/neuropsych tests (MMSE 12–26, CDR 0.5–2)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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