Orexin system and nicotine addiction study
Part of Mental health clinical trials.
This study looks at how a brain chemical called orexin affects nicotine addiction. It may help find new ways to treat smoking addiction.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must smoke at least 10 cigarettes a day and have been smoking for 2 or more years.
- You need to be able to talk with the researchers and follow their instructions.
- You must not have mental health problems like psychosis or a family history of them.
- You must not have other addictions (like to alcohol, drugs, gambling, or online games).
- You must not have taken certain sedatives (benzodiazepines) or antipsychotic medicines in the last 2 weeks.
- You must not have epilepsy, a head injury, a coma, brain or serious body illness, and your BMI must be 30 or less.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a non-invasive brain stimulation treatment called deep transcranial magnetic stimulation (TMS) to help adults who smoke heavily and are being treated for opioid use disorder quit smoking. It aims to see if this treatment can reduce cravings and make it easier to stop smoking.
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
This study looks at how a non-invasive brain stimulation technique called TMS (which uses magnetic pulses to stimulate the brain) might affect the brain's reward system in people who smoke. The goal is to understand how to help people quit smoking more effectively.
This study compares how your body and mind respond to your usual menthol cigarettes versus a new menthol cigarette. Researchers want to understand how different menthol cigarettes affect smoking behavior and cravings over two weeks.
This study tests whether a brain stimulation treatment called rTMS can help people with psychiatric conditions quit smoking. You will be randomly assigned to get either rTMS or a nicotine patch, and your progress will be tracked to see which treatment works better.
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Hear when a new Tobacco Use Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.