Testing orexin effects to reduce nicotine addiction
Part of Mental health clinical trials.
This study looks at how a brain system called orexin may affect nicotine addiction. If you smoke regularly and meet diagnostic criteria, the trial may help researchers understand what brain changes could improve nicotine dependence.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are diagnosed with nicotine (tobacco) dependence based on DSM-5 criteria
- You smoke at least 10 cigarettes per day for at least 2 years
- You can talk normally with the study team and follow study instructions
- You cannot have major mental health problems like psychosis, or a family history of mental disorders
- You must not have other addiction issues (like gambling or online gaming) besides nicotine (and alcohol/drugs if allowed)
- You must be able to have MRI scans and not recently use certain medicines
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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