Umbilical cord stem cells for ankylosing spondylitis
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial tests whether a single infusion of stem cells from donated umbilical cord tissue is safe and well-tolerated in people with active ankylosing spondylitis (AS). It may reduce inflammation and help control symptoms when standard treatments are not working well enough.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of ankylosing spondylitis (AS) and have active symptoms (such as pain, stiffness) measured by a standard questionnaire (BASDAI score of 4 or higher).
- You must have tried at least 2 different non-steroidal anti-inflammatory drugs (NSAIDs, like ibuprofen or naproxen) for at least 4 weeks without enough improvement, or you were unable to tolerate them.
- You can be on certain medications like methotrexate, sulfasalazine, or prednisone (≤10 mg per day), but the dose must have been stable for at least 4 weeks before starting the trial.
- You must not have taken biologics (like TNF blockers) in the 3 months before the trial, and must not have had stem cell therapy before.
- You must not have severe medical conditions like recent heart attack, stroke, active infections, or hepatitis B or C, and your organ function (liver, kidneys, heart) should be within safe limits.
- If you are able to have children, you agree to use effective birth control during the trial and for at least 6 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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