Clin2
NCT05964192Possibly a fitRecruiting

Neuro test help after rTMS for treatment-resistant depression

Major Depression

Part of Mental health clinical trials.

This study checks whether a set of brain and hormone-related blood/marker tests can help predict or improve how well rTMS works for depression. It’s for adults whose depression has not responded to two antidepressants.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
50 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You have an episode of depression diagnosed using DSM-5 criteria
  • You are between 18 and 65 years old
  • You’ve had two good-quality antidepressant trials that didn’t work (and your depression score is high enough, HAMD-17 ≥ 18)
  • You can sign consent to join the study
  • You have health/social security coverage or benefits
  • You are not pregnant or breastfeeding

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07673913Recruiting
Blood markers and brain stimulation for hard-to-treat depression

This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.

Ankara, Ankara
NCT04041479Recruiting· Phase 3
Brain-scan guided rTMS for treatment-resistant depression

This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.

Stanford, California
NCT05139862Not yet recruiting
Predicting treatment response for depression using brain and heart tests

This study is testing whether brain and heart signals can help predict who will respond to rTMS, a non-invasive treatment that uses magnetic pulses to stimulate parts of the brain. You would receive rTMS for depression and undergo MRI scans and heart monitoring to see if certain patterns predict improvement.

Vancouver, British Columbia
NCT06719427Recruiting· Phase 1
Brain waves study for depression treatment with rTMS

This study looks at brain wave patterns in people with depression who are receiving a type of brain stimulation called rTMS. It aims to understand how the brain changes during recovery, which may help improve future treatments.

North York, Ontario
NCT03348761Recruiting
Brain stimulation for depression after antidepressants didn’t help

This study tests a non-invasive brain stimulation treatment (repetitive transcranial magnetic stimulation, or rTMS) in people with major depression who did not respond to antidepressant medicines. It may help some participants improve depression symptoms over time.

Hong Kong
NCT05813093Recruiting
Brain stimulation and brain scans for hard-to-treat depression

This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.

Toronto, Ontario

Hear when a new Major Depression trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.