Blood markers and brain stimulation for hard-to-treat depression
Part of Mental health clinical trials.
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Ages 18 to 55.
- Diagnosed with major depressive disorder (depression) that hasn't improved after at least two different antidepressant medicines.
- Able to attend study visits and complete brain-stimulation sessions (called transcranial magnetic stimulation, or TMS for short).
- No metal implants in the head, such as a pacemaker or cochlear implant, and no history of epilepsy, brain tumor, or severe head trauma.
- No active infections, autoimmune or inflammatory diseases, and not pregnant or breastfeeding.
- No use of certain other treatments in the past 5 years, including electroconvulsive therapy (ECT), deep brain stimulation, vagus nerve stimulation, or ketamine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new type of brain stimulation treatment for people with major depression that hasn't improved with standard treatments. The treatment uses magnetic pulses to target specific brain areas over about 2 weeks.
This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Hear when a new Major Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.