Brain stimulation for depression after antidepressants didn’t help
Part of Mental health clinical trials.
This study tests a non-invasive brain stimulation treatment (repetitive transcranial magnetic stimulation, or rTMS) in people with major depression who did not respond to antidepressant medicines. It may help some participants improve depression symptoms over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are right-handed
- You have a diagnosis of major depression (a clinician-confirmed diagnosis)
- Your depression severity score is at least moderate on common symptom scales (MADRS and HDRS)
- You tried at least one full course of antidepressant medicine (over 6 weeks) but it didn’t work well, or you couldn’t tolerate it
- You do not have major brain injury (significant head trauma) or certain nervous system conditions
- You can take part safely in rTMS and brain scans (fMRI), meaning no metal implants/pacemakers and not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.
This study looks at brain and heart-related measurements to predict who is most likely to improve with rTMS (repetitive transcranial magnetic stimulation) for depression. It may help future patients by identifying markers of treatment response.
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
This trial tests whether a non-surgical brain stimulation technique (rTMS) can reduce depression symptoms in adults with major depression. You would likely have several study visits that include brain scans (MRI) and treatment sessions to see if symptoms improve.
This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.