Pre-surgery radiation plus immunotherapy and chemo for rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether a short course of radiation before surgery, combined with the immunotherapy drug envafolimab and the chemo regimen CAPEOX, works better for shrinking locally advanced rectal cancer. It is aimed at people whose tumor is not “MMR-deficient” (it is pMMR/MSS), and it asks participants to be able to return for repeated checkups and treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are willing to receive treatment before surgery (preoperative/“neoadjuvant” therapy).
- You are 18 years or older.
- Your rectal cancer is confirmed, and scans show it is within 12 cm of the anus.
- Your tumor is pMMR or MSS (not MMR-deficient and not MSI-H).
- You have not had any anti-cancer treatment or immunotherapy before joining this study.
- You can safely have treatment based on blood tests, and you can return for required visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a combination of short-course radiation, chemotherapy (CapeOx), and an immunotherapy drug (PD-1 inhibitor) for people with early-stage rectal cancer who have had a local excision but are at high risk of the cancer coming back. The goal is to avoid more extensive surgery while still effectively treating the cancer.
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