Pre-surgery radiation plus immunotherapy and chemo for rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether a short course of radiation before surgery, combined with the immunotherapy drug envafolimab and the chemo regimen CAPEOX, works better for shrinking locally advanced rectal cancer. It is aimed at people whose tumor is not “MMR-deficient” (it is pMMR/MSS), and it asks participants to be able to return for repeated checkups and treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are willing to receive treatment before surgery (preoperative/“neoadjuvant” therapy).
- You are 18 years or older.
- Your rectal cancer is confirmed, and scans show it is within 12 cm of the anus.
- Your tumor is pMMR or MSS (not MMR-deficient and not MSI-H).
- You have not had any anti-cancer treatment or immunotherapy before joining this study.
- You can safely have treatment based on blood tests, and you can return for required visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of radiation therapy, chemotherapy, and immunotherapy given before surgery for rectal cancer that has high-risk features. The goal is to shrink the tumor and improve outcomes for patients with this aggressive form of cancer.
This trial tests a combination of short-course radiation, chemotherapy (CapeOx), and an immunotherapy drug (PD-1 inhibitor) for people with early-stage rectal cancer who have had a local excision but are at high risk of the cancer coming back. The goal is to avoid more extensive surgery while still effectively treating the cancer.
This trial tests a new approach for people with locally advanced rectal cancer that has high-risk features. It combines short-course radiation with chemotherapy (CapeOX) and the immunotherapy drug toripalimab, with or without another drug called surufatinib, before surgery. The goal is to see if adding these drugs helps shrink the tumor and improve outcomes.
This study tests whether combining mFOLFOX6 chemotherapy with an immunotherapy drug (anti-PD-1) before surgery can shrink locally advanced rectal cancer. It is open to people whose tumors are mismatch repair proficient (pMMR) or microsatellite stable (MSS).
This trial tests whether combining radiation and chemotherapy with two immunotherapy drugs can better treat locally advanced rectal cancer (no spread to distant organs). It may shrink the tumor before surgery, and if you are enrolled, you will receive this combination as part of the study.
This trial tests whether adding a new immunotherapy drug (cadonilimab) to standard chemoradiation before surgery helps patients with locally advanced rectal cancer. It aims to improve treatment outcomes by using a shorter course of radiation followed by a combination of the immunotherapy and chemotherapy.
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