Close the left atrial appendage after stroke despite blood thinners
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether closing a heart pouch called the left atrial appendage can prevent future strokes in people with atrial fibrillation who had an ischemic stroke even while taking blood thinners. It may help reduce stroke risk by blocking a common place where clotting can start.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and can sign consent
- You have atrial fibrillation (it can be permanent, persistent, or comes and goes)
- You had an ischemic stroke within the last 3 months
- You were actively taking a blood thinner at the time of the stroke (not stopped for more than 48 hours)
- You can take a DOAC (a type of blood thinner like apixaban or rivaroxaban) now or long-term
- Your doctor does not find reasons you cannot safely take DOACs or do the heart ultrasound exam needed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a procedure that seals off the left atrial appendage (a small heart pouch) to help prevent stroke in people with atrial fibrillation. You may be considered if your stroke risk is high and you are already on blood-thinner medicine.
This trial studies whether closing off part of the heart (the left atrial appendage) can prevent stroke as well as long-term newer blood-thinner pills. It may help people with atrial fibrillation who recently had a stroke or a warning stroke (TIA).
This trial tests a procedure to close off a small pouch in the heart called the left atrial appendage, which is a common source of blood clots in people with atrial fibrillation. The goal is to lower your stroke risk without needing to take blood thinners long-term.
This study tests a procedure called left atrial appendage occlusion. It blocks off a small pouch in the heart where blood clots can form, to reduce stroke risk without needing long-term blood thinners. This might help kidney dialysis patients who have atrial fibrillation, even though they are on dialysis.
This trial tests the Zenith system, a device that seals off a heart area called the left atrial appendage to reduce stroke risk in people with atrial fibrillation (AF). You may be eligible if you have AF and a doctor recommends LAA closure, and you can return for follow-up scans and visits.
This trial tests whether patients who receive a special device to close a hole in the heart (to prevent stroke from irregular heartbeat) can safely take fewer blood-thinning medications afterward. The study compares taking a standard blood thinner for 3 months versus taking aspirin only, to see which approach works best with fewer bleeding risks.
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