Compare a heart procedure to blood-thinner pills for stroke prevention
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial studies whether closing off part of the heart (the left atrial appendage) can prevent stroke as well as long-term newer blood-thinner pills. It may help people with atrial fibrillation who recently had a stroke or a warning stroke (TIA).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 years or older
- You have a diagnosis of atrial fibrillation that is not related to a heart valve problem
- You can take long-term newer blood-thinner pills (NOACs)
- You had an ischemic stroke in the last 6 months, or a TIA in the last 6 months with MRI proof of brain blood-flow injury
- Your disability score is not more than moderate (modified Rankin scale 3 or less)
- Your kidneys work well enough for study treatment (GFR 15 or higher)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether closing a heart pouch called the left atrial appendage can prevent future strokes in people with atrial fibrillation who had an ischemic stroke even while taking blood thinners. It may help reduce stroke risk by blocking a common place where clotting can start.
This trial tests whether patients who receive a special device to close a hole in the heart (to prevent stroke from irregular heartbeat) can safely take fewer blood-thinning medications afterward. The study compares taking a standard blood thinner for 3 months versus taking aspirin only, to see which approach works best with fewer bleeding risks.
This study tests a procedure that seals off the left atrial appendage (a small heart pouch) to help prevent stroke in people with atrial fibrillation. You may be considered if your stroke risk is high and you are already on blood-thinner medicine.
This study looks at whether a lower-dose blood thinner works as well as the usual recommended anti-clot treatment after a procedure that closes off the heart’s left atrial appendage. It may help reduce bleeding risk while still preventing dangerous blood clots.
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
This study tests a combined approach — a catheter ablation to fix the irregular heartbeat (atrial fibrillation) and a device to close the left atrial appendage — in people who recently had a stroke caused by a clot. The goal is to prevent future strokes and reduce the need for long-term blood thinners.
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