Comparing immunotherapy to radiation after successful treatment for head and neck cancer
Treatments studied
Part of Cancer clinical trials.
This trial looks at whether giving an immunotherapy drug (a PD-1 inhibitor) after surgery is better than giving radiation therapy for people with advanced head and neck cancer who had a complete response to chemotherapy and immunotherapy before surgery. The goal is to prevent the cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced head and neck squamous cell carcinoma that has been surgically removed after chemotherapy and immunotherapy, and there was no cancer left in the removed tissue.
- You are between 18 and 65 years old.
- Your blood counts, liver and kidney function, thyroid, and heart tests are within a certain range.
- You have not had other cancers, active autoimmune diseases, or serious infections like HIV or untreated hepatitis B or C.
- You are not pregnant or breastfeeding, and you agree to use effective birth control during the study and for several months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial compares two different treatments after surgery for advanced head and neck cancer (oral or oropharyngeal). It tests whether radiation therapy or continuing an immunotherapy drug (called PD-1 inhibitor) leads to better survival. This study might help you decide which follow-up treatment could be better for your situation.
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This trial compares giving immunotherapy alone versus immunotherapy plus focused radiation before surgery for head and neck cancer. The goal is to see if adding radiation helps shrink the tumor and improve outcomes.
This trial tests if adding immunotherapy after standard chemoradiation helps prevent cancer from returning in people with high-risk head and neck cancer. It is for those who have completed surgery and have certain high-risk features.
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