Radiation or immunotherapy after surgery for head and neck cancer
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This trial compares two different treatments after surgery for advanced head and neck cancer (oral or oropharyngeal). It tests whether radiation therapy or continuing an immunotherapy drug (called PD-1 inhibitor) leads to better survival. This study might help you decide which follow-up treatment could be better for your situation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old
- You have been diagnosed with locally advanced oral or oropharyngeal squamous cell carcinoma (a type of head and neck cancer)
- You have already received 2 cycles of neoadjuvant chemoimmunotherapy (combination of chemotherapy and immunotherapy) and had surgery to remove all visible cancer (R0 resection)
- You must not have had any prior cancer treatment before the neoadjuvant therapy
- You must not have distant spread of cancer (metastasis)
- Your overall health is good (ECOG performance status 0-1), and you do not have severe heart, liver, or kidney problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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