Stem cell therapy for acute-on-chronic liver failure
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether stem cells from donated umbilical cords can help people with acute-on-chronic liver failure, a sudden worsening of chronic liver disease. The goal is to see if this treatment improves liver function and survival.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have chronic liver disease or cirrhosis and recently developed severe jaundice (high bilirubin) and bleeding problems (low clotting factors).
- You have not needed a liver transplant in the past and are not planning one within the next 3 months.
- You do not have active kidney injury, uncontrolled bleeding, serious confusion (hepatic encephalopathy), or infections at the start of the trial.
- You are not pregnant, breastfeeding, or planning a pregnancy soon.
- You have not received stem cell therapy or been in another clinical trial in the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a special type of stem cell therapy can help people with severe liver failure (called ACLF) that is not caused by a virus. The treatment may help your liver recover and improve your overall condition.
This study tests whether a special type of stem cell therapy (called mesenchymal stem cells) can help people with a severe liver condition called acute-on-chronic liver failure (ACLF). The goal is to see if this treatment can improve liver function and reduce the need for a liver transplant.
This study tests whether a treatment made from stem cells (cells that can help repair tissues) can improve liver function in people with a sudden worsening of long-term liver disease. The stem cells are given through a vein, and the goal is to see if they help the liver recover without needing a transplant.
This trial tests whether a stem cell infusion made from umbilical cord tissue can help people with severe liver failure caused by hepatitis B. The stem cells may reduce liver damage and improve recovery.
This trial looks at how well stem cell (MSC) treatment works for people with severe liver failure caused by hepatitis B. It checks what factors affect the success of the treatment.
This Phase 1 study tests a new way to place liver cells (in small protective “micro-packages”) inside the belly to treat liver failure. It aims to see whether the treatment is safe and potentially helps liver function in adults with worsening chronic or acute-on-chronic liver failure.
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