Stem cell therapy for acute-on-chronic liver failure
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether stem cells from donated umbilical cords can help people with acute-on-chronic liver failure, a sudden worsening of chronic liver disease. The goal is to see if this treatment improves liver function and survival.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have chronic liver disease or cirrhosis and recently developed severe jaundice (high bilirubin) and bleeding problems (low clotting factors).
- You have not needed a liver transplant in the past and are not planning one within the next 3 months.
- You do not have active kidney injury, uncontrolled bleeding, serious confusion (hepatic encephalopathy), or infections at the start of the trial.
- You are not pregnant, breastfeeding, or planning a pregnancy soon.
- You have not received stem cell therapy or been in another clinical trial in the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether infusing stem cells (from a healthy donor) can help people with sudden liver failure that is not getting better with standard medicines and is not caused by viruses. It aims to improve liver function and possibly avoid the need for a transplant.
This early-phase study tests whether stem cells (called mesenchymal stem cells) are safe and can help people with a sudden, severe liver failure. You may qualify if your liver is failing quickly and you are not eligible for a transplant.
This trial tests whether injecting special stem cells (called mesenchymal stem cells) can help people with a sudden worsening of chronic liver disease (called acute-on-chronic liver failure) who do not have a virus as the cause. It is for patients who are too sick for standard treatment but who cannot get a liver transplant right away.
This trial tests if infusions of stem cells from donated umbilical cords can help people with a severe type of liver failure caused by hepatitis B. It aims to see if the treatment is safe and can improve liver function.
This trial looks at how well stem cell (MSC) treatment works for people with severe liver failure caused by hepatitis B. It checks what factors affect the success of the treatment.
This trial tests whether a single infusion of umbilical cord stem cells can help people recover from a recent ischemic stroke (stroke caused by a clot). It is for patients who have had their stroke within the last 72 hours and have moderate to severe symptoms.
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