Testing a new drug with fulvestrant for advanced breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a new pill (M1774) combined with a hormone therapy called fulvestrant for people with advanced hormone-receptor-positive, HER2-negative breast cancer that has stopped responding to standard hormone therapy and CDK4/6 inhibitors. The study focuses on people with certain genetic markers in their tumor, hoping the combination will work better than current options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older and have advanced breast cancer that is hormone-receptor positive and HER2-negative.
- Your cancer must have progressed (grown) during or soon after treatment with an aromatase inhibitor (like letrozole) plus a CDK4/6 inhibitor (like palbociclib).
- You must have certain genetic changes in your tumor (like BRCA1/2, PALB2, or others listed) that make the study drug more likely to work.
- You can't have had more than one prior chemotherapy for advanced disease, and you can't have had fulvestrant before.
- You need to be able to swallow pills and have adequate organ function, good performance status (ECOG 0 or 1), and measurable disease by scans.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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