Clin2
NCT06003153Possibly a fitRecruiting

Gene and sugar response study with oral semaglutide

Genetic PredispositionMetabolic DiseasesType 2 Diabetes

Treatments studied

Part of Hormones & metabolism clinical trials.

This study looks at how your genes affect your body's response to a diabetes medication called semaglutide. It may help people with slightly high blood sugar (pre-diabetes) understand why some respond better than others.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
125 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You are between 18 and 65 years old
  • You are male, or female and not pregnant
  • Your fasting blood sugar is between 100 and 125 mg/dL based on past lab results
  • You are not currently taking medication for diabetes
  • You have not had weight loss surgery, gallbladder disease, pancreatitis, or certain digestive issues
  • You do not have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06069622Recruiting
How a gene affects weight-loss treatment response

This study looks at how a weight-loss medication affects people with obesity who may have a specific gene difference (caveolin-1). It aims to understand why some people respond differently to GLP-1 treatments like semaglutide.

Boston, Massachusetts
NCT05340868Recruiting
Study body response to oral semaglutide in overweight adults

This study looks at how genetics may affect your body’s early response to oral semaglutide, a weight-related diabetes medicine. You may be considered if you are overweight (or overweight with prediabetes) and can safely take part in the research.

Bialystok, Podlaskie Voivodeship
NCT05071898Recruiting· Phase 1
Studying how genetics affect response to GLP-1 weight-loss drugs

This early-stage study looks at how genetic factors may change how people respond to a GLP-1 medicine (semaglutide). The goal is to learn who may benefit most and why, so future treatments can be better matched.

Lancaster, Pennsylvania
NCT05119179Recruiting· Phase 4
Testing how genetics affect GLP-1 response in prediabetes

This study looks at how your genes may change how well a GLP-1–type medicine works to improve prediabetes. It focuses on adults at higher risk of developing diabetes, especially people of Mexican-American background.

Brownsville, Texas
NCT06909006Not yet recruiting· Phase 3
Semaglutide for adults with type 1 diabetes and overweight

This study tests whether semaglutide, a medicine that helps control blood sugar and reduce weight, can benefit adults with type 1 diabetes who are overweight. If you qualify, you may receive the drug or a placebo, and the study team will monitor your health closely.

Hillerød, Denmark
NCT07415954Recruiting· Phase 2
Testing a new diabetes medicine for blood sugar control

This study tests a new medicine, NNC0662-0419, in people with type 2 diabetes. You must be willing to lose a lot of weight (more than a quarter of your current weight) as part of the study to see if the medicine helps lower blood sugar.

Lancaster, California

Hear when a new Genetic Predisposition trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.