HIV reservoir study in people who control the virus
Part of Immune system & allergy, Infections clinical trials.
This study looks at the hidden HIV 'reservoir' in people who naturally control the virus or who have controlled it after stopping treatment. It aims to understand why some people's immune systems can keep HIV in check, which could lead to new treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a person living with HIV who can control the virus without medication (elite controller, viral controller, or long-term non-progressor).
- Or you have stopped HIV treatment and kept your viral load low for 2 years (post-treatment controller).
- Or you have received a bone marrow transplant for a non-HIV reason.
- You must not have active hepatitis B or C, certain heart conditions, cancer, or a history of HIV-related low platelets.
- You must be willing to avoid certain immune-modifying drugs for 3 months before and during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This international study looks at blood samples from people with HIV to find markers that predict whether someone can control the virus without medication. It involves four groups: natural controllers, people who controlled virus after stopping treatment in a study, non-controllers (whose virus returns), and people stable on ART.
This study in Uganda looks at the HIV 'reservoir' (where the virus hides in the body) in people whose HIV is already well-controlled with medications. It involves blood draws and genetic testing to learn more about the virus.
This study compares how active the immune system is and how large the “hidden” HIV reservoir is in people on two different HIV treatment types. It may help researchers understand whether staying on a tenofovir-containing regimen leads to better control of HIV hiding in the body.
This study looks at how platelets (small blood cells that help with clotting) might influence the hidden HIV that remains in your body even when your viral load is undetectable. The goal is to understand why some people's immune systems don't fully recover despite effective HIV treatment.
This study looks at why some people with HIV have very low but detectable virus in their blood despite taking their HIV medications. It may help doctors understand how the virus hides in the body.
This study tests whether a combination approach, including a drug called nicotinamide (a form of vitamin B3) and other strategies, can reduce the hidden HIV reservoir enough to allow a temporary pause in antiretroviral therapy without the virus rebounding. It is for people who have well-controlled HIV and strong immune systems.
Hear when a new HIV trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.