Knee procedure for advanced arthritis pain
Part of Bones, joints & muscles clinical trials.
This study tests a procedure called subchondroplasty, which treats knee pain from advanced osteoarthritis (wear-and-tear arthritis) when other treatments have not helped. It may help people who want to delay or avoid knee replacement surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your body mass index (BMI) is 35 or less.
- You have advanced knee arthritis (grade 3 or 4 on the Kellgren-Lawrence scale), confirmed by MRI and X-ray.
- You have bone marrow lesions in the knee, seen on MRI at least 3 months ago.
- You have severe knee pain that limits walking to 500 meters or less, and previous treatments (like injections) have not helped.
- You are willing to follow study procedures, including follow-up visits and rehabilitation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether platelet-rich plasma (a treatment made from your own blood) can reduce symptoms of knee osteoarthritis. It focuses on people with specific types of knee pain and X-ray findings, and compares against rules around current pain medicines and injections.
This study compares a new plastic-and-metal knee implant to a standard metal one for people with severe knee arthritis. If you need a total knee replacement and your knee is not too bent or twisted, you may be a candidate.
This study uses fat tissue from your own body, processed with a special device, and injects it into the knee to help reduce pain and improve function in knee osteoarthritis. It's a minimally invasive treatment that might be an option for people who have not found relief from other treatments.
This trial tests a new injectable filler called ALLOHEAL, injected directly into the knee joint to reduce pain and improve function in people with knee osteoarthritis. The filler is designed to cushion the knee joint and may help reduce pain and stiffness.
This study tests whether two types of platelet-rich plasma (a treatment made from your own blood) can help relieve severe knee osteoarthritis pain when injected into the bone and joint. It may offer a non-surgical option for people whose knee pain limits walking.
This trial compares using cells from your bone marrow or belly fat to treat knee osteoarthritis, aiming to reduce pain and improve function. It's for people who haven't gotten better with standard treatments like physical therapy or medications.
Hear when a new Knee Osteoarthritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.