Clin2
NCT06031727Possibly a fitRecruiting

CRISPR gene therapy for wet age-related macular degeneration

Neovascular Age-related Macular Degeneration(nAMD)

Part of Eyes & vision clinical trials.

This trial tests a new CRISPR-based treatment for wet age-related macular degeneration (AMD). It aims to stop vision loss by targeting the cause of abnormal blood vessel growth in the eye. This study is for people who have already tried anti-VEGF injections but might not be responding well enough.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
12 people
Ages
50 years to 80 years
Study type
Interventional

Who can take part

  • You are between 50 and 80 years old.
  • You have wet AMD in at least one eye, with vision between 20/32 and 20/320 in that eye.
  • Your other eye has vision of 20/400 or better.
  • You have had anti-VEGF injections in the past and either responded to them or have not responded well (fluid that didn't improve).
  • You have no other eye problems (like glaucoma or previous surgeries) that could limit vision or healing.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06623279Not yet recruiting· Phase 1
Gene therapy trial for wet age-related macular degeneration

This trial tests a new CRISPR-based gene therapy injected into the eye to treat wet age-related macular degeneration (AMD). It aims to stop the growth of abnormal blood vessels that damage your vision.

NCT07482176Recruiting· Phase 3
Gene therapy trial for wet age-related macular degeneration

This trial tests a one-time gene therapy injection (IXO-vec) for people with wet age-related macular degeneration (nAMD). It aims to reduce the need for frequent eye injections by helping the eye make its own medicine to block the growth of harmful blood vessels.

Mesa, Arizona
NCT07064759Recruiting· Phase 3
Gene therapy injection for wet age-related macular degeneration

This trial tests a one-time gene therapy injection (4D-150) for wet AMD. It might help reduce the need for frequent anti-VEGF eye injections by targeting the underlying cause of new blood vessel growth.

Scottsdale, Arizona
NCT07317934Recruiting· Phase 3
Gene therapy for wet age-related macular degeneration

This study tests a one-time gene therapy called LX102 for wet age-related macular degeneration (AMD). It may reduce the need for frequent eye injections and help preserve vision.

Hefei, Anhui
NCT07053358Recruiting· Early Phase 1
Gene therapy for wet AMD

This trial tests a new gene therapy (LX111) for people with wet age-related macular degeneration (AMD) who have already been helped by standard anti-VEGF injections. The goal is to see if one dose of LX111 can reduce the need for frequent eye injections.

Shanghai
NCT07275840Recruiting· Phase 2
Testing IBI302 for wet age-related macular degeneration

This study tests a new medicine called IBI302 for wet age-related macular degeneration (AMD). It aims to slow vision loss by targeting both blood vessel growth and inflammation. You might qualify if you have active wet AMD and have not had certain injections recently.

Shanghai, Shanghai Municipality

Hear when a new Neovascular Age-Related Macular Degeneration (nAMD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.