Combination therapy for jaw bone damage after radiation
Part of Cancer, Injuries & trauma clinical trials.
This trial tests a combination of hyperbaric oxygen therapy and a medication called PENTOCLO to treat osteoradionecrosis (bone damage) in the jaw after radiation treatment for cancer. It may help heal the exposed bone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have exposed bone in your jaw (larger than a small coin) that started after radiation therapy.
- You are able to undergo 60 sessions of hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber).
- You have not had any prior treatment for this bone damage, such as PENTOCLO, hyperbaric oxygen, or surgery.
- You do not have any major health issues that would make the treatments unsafe, like uncontrolled high blood pressure or epilepsy.
- You are not pregnant, breastfeeding, or taking blood-thinning medications.
- You are at least 18 years old.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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