Risk factors for jaw bone damage after radiation for mouth cancer
Part of Cancer, Injuries & trauma, Mouth & dental clinical trials.
This study looks at people who had radiation therapy for oral cavity (mouth) cancer to find out why some develop a serious side effect called osteoradionecrosis (when the jaw bone doesn't heal and dies). They will review medical records to identify risk factors, which may help doctors better protect patients’ jaw health during and after radiation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You were diagnosed with cancer in the oral cavity (mouth area) and received radiation therapy with the goal of cure (not just to relieve symptoms).
- You completed your full prescribed course of radiation therapy (or had to stop because of a suspected jaw problem that turned out to be osteoradionecrosis).
- Your radiation therapy was completed on or before December 31, 2024, and you have at least 24 months of follow-up information after radiation.
- Your medical records are complete, including details about your radiation treatment, dental status, other health conditions, and any dental procedures.
- You have not taken bone-strengthening medications like bisphosphonates or denosumab, or anti-angiogenic drugs.
- Your jaw problem is not caused by something other than radiation (such as dental infection, trauma, or medication-related jaw death).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is a “real-world” registry that follows people with jaw problems related to cancer or cancer treatment. It looks at how well jaw reconstruction with dental implants and fixed teeth works when removable dentures are not suitable.
This trial uses repeated MRI scans to better predict which patients may develop painful jaw and mouth tissue problems after radiation and/or certain bone or blood-vessel medicines. It may help clinicians spot problems earlier and tailor follow-up care.
This trial tests a combination of hyperbaric oxygen therapy and a medication called PENTOCLO to treat osteoradionecrosis (bone damage) in the jaw after radiation treatment for cancer. It may help heal the exposed bone.
This study uses special MRI scans with contrast to better detect osteoradionecrosis (jaw bone injury) after radiation for head and neck cancer. If you qualify, the scans may help your team diagnose problems earlier and choose the right next treatment.
This study uses special MRI scans before and after radiation therapy to see if they can predict damage to your jawbone. If you are getting radiation to the head or neck area, this study may help monitor side effects.
This study looks at how to manage impacted wisdom teeth during radiation therapy for nasopharyngeal cancer, to try to reduce the risk of a serious side effect called osteoradionecrosis (where the jawbone doesn't heal properly after radiation). If you qualify, you'll be in a trial that may help guide safer dental care during cancer treatment.
Hear when a new Osteoradionecrosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.