Testing pentoxifylline and vitamin E for jaw bone damage
Part of Bones, joints & muscles, Mouth & dental clinical trials.
This trial tests a combination of medicines (pentoxifylline and tocopherol, a form of vitamin E) to treat damage to the jaw bone caused by bone-strengthening drugs. If you have Stage 2 MRONJ and meet other criteria, this treatment may help heal the bone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have taken or are taking a type of bone medication (bisphosphonate or denosumab).
- Your jaw has an exposed area of bone with signs of infection (this is called Stage 2 MRONJ).
- You have not had radiation to your head or neck, or cancer that spread to your jaw.
- You are not taking blood thinners, certain other medicines, or have bleeding problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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