Colchicine for heart failure with preserved pumping function
Treatments studied
Part of Heart & circulation clinical trials.
This trial is testing whether colchicine, a medication used for gout, can help people with a specific type of heart failure where the heart pumps normally but is stiff. If you have heart failure with preserved pumping and certain signs of inflammation, this study might be a good fit.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your heart's pumping strength (called LVEF) must be 45% or higher, measured in the last 6 months.
- You must have had heart failure symptoms (like shortness of breath or swelling) for at least 30 days, and currently have them (NYHA class II–IV).
- Your heart must show signs of stiffness or thickening on an ultrasound (echocardiogram).
- A blood test must show a high BNP level (a sign of heart stress): over 125 if your heart rhythm is normal, or over 300 if you have atrial fibrillation.
- Your body mass index (BMI) must be under 40 at the screening visit.
- You cannot be taking colchicine for another reason (like gout), and you must not have serious kidney or liver problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether colchicine can help people with paroxysmal or persistent atrial fibrillation (AF), a type of irregular heartbeat, after a successful cardioversion. It may help reduce future AF problems, depending on the results.
This trial tests if colchicine, an anti-inflammatory medicine, can help people with a type of heart failure where the heart pumps well but is stiff and inflamed. You may join if your heart failure recently worsened and you have signs of inflammation in your blood.
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
This trial tests whether the drug colchicine can help people with heart muscle inflammation (myocarditis) that also causes abnormal heart rhythms, a weak heart pump, or high stress markers. Colchicine is an anti-inflammatory medicine that might reduce heart damage and improve symptoms.
This trial tests whether a low-dose colchicine (LoDoCo) can help people with heart failure and inflammation feel better and exercise more. It is for adults 50 and older with HFpEF who have signs of inflammation in their blood.
This study tests whether colchicine and thiamine (vitamin B1) can improve outcomes in people with heart failure caused by blocked or narrowed heart arteries. It’s mainly for people with moderate-to-severe symptoms and reduced heart pumping ability.
Hear when a new Heart Failure With Preserved Ejection Fraction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.