Colchicine for heart inflammation with arrhythmias
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether the drug colchicine can help people with heart muscle inflammation (myocarditis) that also causes abnormal heart rhythms, a weak heart pump, or high stress markers. Colchicine is an anti-inflammatory medicine that might reduce heart damage and improve symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have inflammation in your heart muscle, confirmed by a heart MRI or PET scan within the last 3 months.
- You have had symptoms for more than 1 month, including at least one of: very frequent extra heartbeats (3,000+ per day), short runs of fast heartbeats, or sustained fast heartbeats; a weaker heart pump (LVEF less than 50% on echo or less than 60% on MRI); or high levels of heart stress markers (NT-proBNP over 1,000 or BNP over 200).
- You are not currently taking colchicine or other immune-suppressing drugs, and you do not have severe kidney or liver disease.
- You are not pregnant or breastfeeding, and you do not have other serious conditions like recent heart attack, blocked arteries, or certain autoimmune diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
This trial tests whether a low-dose colchicine (LoDoCo) can help people with heart failure and inflammation feel better and exercise more. It is for adults 50 and older with HFpEF who have signs of inflammation in their blood.
This study tests whether colchicine and thiamine (vitamin B1) can improve outcomes in people with heart failure caused by blocked or narrowed heart arteries. It’s mainly for people with moderate-to-severe symptoms and reduced heart pumping ability.
This trial tests whether colchicine (a medicine that reduces inflammation) improves outcomes in people with acute myocarditis soon after symptoms start. Half of participants get colchicine and half get a placebo to see which works better.
This trial tests whether colchicine can help people with paroxysmal or persistent atrial fibrillation (AF), a type of irregular heartbeat, after a successful cardioversion. It may help reduce future AF problems, depending on the results.
This study tests whether the drug colchicine can reduce inflammation in people with coronary heart disease who have had a stent placed. It aims to see if colchicine helps improve heart health by lowering inflammation.
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