Colchicine for heart failure with preserved pump function and inflammation
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests if colchicine, an anti-inflammatory medicine, can help people with a type of heart failure where the heart pumps well but is stiff and inflamed. You may join if your heart failure recently worsened and you have signs of inflammation in your blood.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your heart's pumping strength is normal or nearly normal (≥50%).
- You have been hospitalized or had urgent treatment for heart failure in the past 30 days.
- Your blood test shows high levels of NT-proBNP (a heart strain marker) and CRP (an inflammation marker).
- You have not taken colchicine in the last month.
- You do not have severe kidney or liver disease, certain digestive issues, or active cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
This trial tests whether a low-dose colchicine (LoDoCo) can help people with heart failure and inflammation feel better and exercise more. It is for adults 50 and older with HFpEF who have signs of inflammation in their blood.
This trial tests whether the drug colchicine can help people with heart muscle inflammation (myocarditis) that also causes abnormal heart rhythms, a weak heart pump, or high stress markers. Colchicine is an anti-inflammatory medicine that might reduce heart damage and improve symptoms.
This trial tests whether colchicine (a medicine used for gout) can help prevent heart problems after a stent procedure (PCI). It's for people who are in the hospital getting a stent and follow standard heart care.
This study tests whether colchicine and thiamine (vitamin B1) can improve outcomes in people with heart failure caused by blocked or narrowed heart arteries. It’s mainly for people with moderate-to-severe symptoms and reduced heart pumping ability.
This trial tests whether a low dose of the anti-inflammatory drug colchicine can help people who have recently had a heart attack or unstable angina. It aims to see if colchicine reduces the risk of future heart problems.
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