CAR T-Cell Therapy for Advanced Sarcoma in Young People
Part of Bones, joints & muscles, Cancer clinical trials.
This trial tests a special type of immune cell (called a CAR T-cell) that is trained to attack sarcoma cells. It is for children, teens, and young adults up to age 40 whose sarcoma has not responded to standard therapy. The treatment is given directly into the tumor, and the goal is to see if it is safe and how well it works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 40 years old or younger with a type of sarcoma (a cancer of the bones or soft tissues) that has not been cured by standard treatments.
- Your tumor has a certain protein (called NKG2D ligand) that can be measured in a small sample (biopsy).
- You are feeling well enough to be up and active at least half the day (a score of 50 or higher on a daily activity scale).
- You have enough healthy blood cells (white cells, platelets, and red cells) and your liver and kidneys are working well.
- You are not pregnant, and you are willing to use effective birth control for 6 months after the infusion (if you are sexually active).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an infusion of activated NK cells (a type of immune cell) to treat sarcomas that are still detectable or not responding well to standard treatment. If you qualify, you may receive this cell therapy while doctors closely check your organ function and heart strength.
This trial tests a new kind of cell therapy called CAR T-cells that are engineered to find and attack sarcoma cells carrying a marker called B7-H3. It is for children and young adults whose sarcoma has come back or not gone away after treatment.
This trial tests a new type of immune cell therapy (4th generation CAR T cells) designed to recognize and attack sarcoma cells. It's for people with advanced or recurrent sarcoma whose tumors have a specific marker.
This trial tests a new type of immunotherapy where your own immune cells are modified to find and attack sarcoma cells that carry markers called CD146 or HER2. It is for people with advanced sarcoma who have already tried standard treatments.
This trial tests a combination of targeted radiation and special immune cells (CAR T cells) for children and young adults whose bone or soft tissue sarcoma has come back or not responded to standard treatments. The CAR T cells are made from your own blood cells and are designed to attack a protein called B7-H3 found on the sarcoma cells.
This trial tests a new type of cell therapy called B7-H3 CAR T cells for children and young adults with high-risk osteosarcoma that hasn't spread or worsened after standard chemotherapy. The treatment uses your own immune cells that are modified to attack a protein (B7-H3) found on cancer cells.
Hear when a new Advanced Sarcoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.