Preserving fatty livers with a machine for transplant
Part of Digestive system clinical trials.
This study tests a new way to preserve donated livers that have extra fat (steatotic livers) using a special machine that keeps the liver healthy outside the body. If successful, it could allow more livers to be used for transplantation, helping people on the waiting list get a transplant sooner.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You are on the waiting list for a liver transplant at Massachusetts General Hospital (MGH).
- Your MELD-Na score (a measure of liver disease severity) is 25 or lower.
- You are not listed as Status 1a (the most urgent transplant category).
- You do not have significant heart or lung disease, and you have not had a prior liver transplant.
- You are not currently on blood pressure support medications (pressors), and you are not someone with a low MELD score (under 15) who has no symptoms from liver disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new way to preserve donated livers using a special machine that keeps the liver cool and pumps fluid through it before transplantation. This may help the liver stay in better condition for the recipient, which could improve transplant success.
This study looks at a way to predict whether a donated liver will work well after being kept alive outside the body (“machine perfused”). It may help doctors choose the best livers and improve transplant outcomes.
This trial tests whether using a machine to keep donated livers healthy (normothermic machine perfusion) can allow more people to receive a transplant sooner. It is for patients who are already on the waiting list for a liver and have a moderately severe MELD score (25 or less).
This trial tests a new way to check if a donated liver is healthy while it is kept on a machine that keeps it alive before transplant. Doctors measure a substance called FMN in the fluid that flows through the liver and in bile. This could help them know how well the liver might work after transplant.
This study collects information about how livers do after transplantation when they've been preserved using machine perfusion—a technique that keeps donor livers in better condition before surgery. Researchers want to understand which preservation methods work best to improve transplant success across Europe.
This study tests a new way to check donated livers that other transplant centers have turned down. The goal is to see if these livers can be safely used for people on the waiting list, potentially increasing the number of available organs.
Hear when a new Liver Transplant trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.