Esketamine vs. ketamine for hard-to-treat depression
Part of Mental health clinical trials.
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have major depression that hasn't gotten better with at least two prior antidepressant treatments
- Your depression is moderate to severe as measured by a standard rating scale
- You are not pregnant, breastfeeding, or of childbearing potential without using highly effective birth control
- You do not have bipolar disorder or a psychotic disorder
- You do not have a current or recent substance use disorder (except nicotine) and haven't had too many prior ketamine or esketamine treatments
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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