Losartan to prevent knee stiffness after replacement
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests whether losartan, a blood pressure medicine, can prevent excessive scar tissue (arthrofibrosis) after a total knee replacement. Participants receive losartan or a placebo for 6 months after surgery to see if it improves knee motion and reduces stiffness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for a first-time total knee replacement on one knee.
- You are 18 years or older.
- You are not pregnant, breastfeeding, or planning to become pregnant during the study.
- You do not have an autoimmune arthritis (like rheumatoid arthritis) affecting the knee.
- You are not currently taking losartan, warfarin, or other blood thinners.
- You are willing to stop opioid pain medications (except right after surgery) for the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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