Clin2
NCT06152705Possibly a fitRecruiting

fMRI-Guided vs. Standard Brain Stimulation for Depression

DepressionDepressive Disorder, MajorDepressive Episode

Part of Mental health clinical trials.

This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
210 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older.
  • You can read and speak English.
  • You have moderate-to-severe depression that hasn't gotten better after trying at least one antidepressant medication.
  • You don't have bipolar disorder or a substance use problem (like alcohol or drug addiction) in the last 3 months.
  • You are not pregnant or planning to become pregnant, and you don't have a metal implant in your head or a history of seizures.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07620288Not yet recruiting
Brain stimulation for depression with imaging

This study tests a type of brain stimulation called theta burst stimulation (TBS) for depression. It uses advanced imaging to see how the brain responds, which may help tailor treatment.

Ottawa, Ontario
NCT07804459Not yet recruiting· Early Phase 1
Personalized brain stimulation for depression

This study uses brain imaging to guide a noninvasive treatment called transcranial magnetic stimulation (TMS) for people with depression. It aims to see if tailoring the stimulation to each person's brain can improve symptoms.

Philadelphia, Pennsylvania
NCT03348761Recruiting
Brain stimulation for depression after antidepressants didn’t help

This study tests a non-invasive brain stimulation treatment (repetitive transcranial magnetic stimulation, or rTMS) in people with major depression who did not respond to antidepressant medicines. It may help some participants improve depression symptoms over time.

Hong Kong
NCT06562153Recruiting
fMRI-guided TMS for depression

This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.

Charleston, South Carolina
NCT04999553Recruiting
Comparing brain stimulation on left vs right side for depression

This study tests whether delivering a type of brain stimulation to the left side of the head is as effective as delivering it to the right side for treating major depression. The treatment is called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate brain areas involved in mood.

Vancouver, British Columbia
NCT07043738Not yet recruiting
Comparing two ways to target brain stimulation for depression

This study tests two methods of targeting repetitive transcranial magnetic stimulation (TMS) for depression: one using brain imaging to guide the treatment, and the other using a standard scalp measurement. The goal is to see if imaging-guided TMS works better for people with treatment-resistant depression.

Hear when a new Depression trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.