Rifampicin plus antibiotics for staph joint replacement infection
Treatments studied
Part of Infections clinical trials.
This study tests whether adding the antibiotic rifampicin to standard treatment works better than standard treatment alone for staph infections in hip or knee replacements. The goal is to find a more effective way to clear the infection and avoid more surgeries.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a staph infection in your hip or knee replacement.
- Your treatment includes surgery plus antibiotics (DAIR procedure).
- You do not have a medical reason to avoid rifampicin (like allergy or drug interactions).
- You do not have a serious staph infection in your blood or heart valves requiring long-term IV antibiotics.
- You are not currently on chemotherapy for cancer, have a life expectancy less than 1 year, or are pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how the antibiotic rifampin behaves in the body when used to treat staph infections in bones or joints. It may help doctors better dose the drug for future patients.
This trial tests whether adding antibiotics to the bone graft used during hip replacement surgery can lower the risk of infection. It may help people who need a bone graft as part of their hip replacement.
This study tests a special antibiotic-coated suture used during surgery to clean infected hip or knee replacements. The goal is to see if it helps prevent the infection from coming back while keeping the original implant in place.
This Phase 3 trial compares two antibiotics—rifabutin and rifampicin—for treating staphylococcal (staph) infections around hip or knee joint implants when the implant is kept in place after cleaning (DAIR). It aims to see which drug works better to stop the infection from coming back.
This study tests whether adding rifampin to standard antibiotics works better for people with a staph infection in a joint replacement. It aims to find a more effective treatment for this type of infection.
This Phase 3 trial tests whether adding rifampicin improves outcomes for implant infections caused by a specific germ (Cutibacterium acnes) after surgery. If you have such an infection and the germ is susceptible, you may be able to receive a rifampicin-based treatment plan.
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