Enasidenib for IDH2-mutated sinonasal and skull base tumors
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial tests an oral targeted therapy called enasidenib for people with rare head and neck cancers that have an IDH2 gene mutation. The goal is to see if this drug can shrink or slow the growth of these tumors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your cancer must have a specific IDH2 gene mutation.
- Tumor must be in the sinonasal cavity or skull base and cannot be fully treated with surgery or radiation.
- You must have had at least one prior systemic treatment (like chemotherapy) that didn't stop the cancer from growing.
- You must have a tumor that can be measured on imaging scans.
- You must be 18 or older and have a good performance status (ECOG 0-2).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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