Comparing one-step vs. two-step valve placement for severe emphysema
Part of Lungs & breathing clinical trials.
This trial tests whether placing ZEPHYR® valves in two stages reduces the risk of a collapsed lung (pneumothorax) compared to the usual one-stage procedure. It is for people with severe emphysema who have already quit smoking and meet specific lung function criteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 35 and 80 years old.
- You have severe emphysema (a type of COPD) confirmed by a recent CT scan (within 6 months).
- You quit smoking at least 3 months ago.
- You have significant shortness of breath (score of 2 or more on a standard questionnaire).
- Your lung function tests show certain specific levels of air trapping and breathing capacity.
- You have not had any lung surgery or valve procedure on the side being treated.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an implantable artificial bronchus to help people with severe emphysema breathe easier. It's for those who have stable COPD, can walk 100–400 meters in 6 minutes, and haven't smoked for at least 4 months.
This study is tracking the real-world use of the Zephyr Valve, a device that helps people with severe COPD breathe easier. It will check if the valve is safe and works well for people in Japan who have been chosen for this treatment by their doctor.
This trial tests a new implant for people with severe emphysema. It aims to see if the implant can help you breathe easier and walk farther.
This study tests a bronchoscopic treatment to release trapped air in severely hyperinflated lungs caused by emphysema. It may help you breathe easier if you have advanced COPD and meet specific lung function and imaging criteria.
Researchers want to see if a bronchoscopic lung volume reduction procedure with Zephyr valves changes how much oxygen your body uses during simple tasks. You may be eligible if you are scheduled for this valve treatment and do not rely on constant oxygen for daily activities.
This trial tests a cell-based treatment placed into the lung using an airway valve, to help people with severe emphysema breathe easier. You may be eligible if your emphysema is uneven in the lungs and testing suggests your “collateral ventilation” is low, meaning the treatment area may benefit more from blocking airflow.
Hear when a new COPD trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.