Testing a nose spray painkiller for sickle cell pain in kids
Treatments studied
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial tests a fentanyl-like nose spray (sufentanil) to relieve severe pain from a sickle cell crisis in children and teens. It aims to see if it works better than usual pain treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have sickle cell disease (types SS, SC, or Sβ-thalassemia)
- You are under 18 years old and weigh more than 22 pounds (10 kg)
- You are in the ER with severe pain from a sickle cell crisis (pain score at least 7/10 or higher on a pain scale)
- You have not taken strong opioids like morphine or fentanyl in the last 6 hours
- You can use a nose spray (no major nose problems, surgery, or nosebleeds)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking ketamine by mouth can help treat “vaso-occlusive” pain episodes that may require hospital admission. If it works, it could offer an easier way to manage severe pain during sickle cell crises.
This trial tests two different nasal sprays (sufentanil vs ketamine) to quickly relieve severe pain from a recent arm or leg injury in children. It aims to find which works better and is safer.
This trial tests if adding lidocaine to standard pain treatment can reduce the amount of morphine or oxycodone needed for a severe pain crisis or acute chest syndrome in sickle cell disease. It is for adults in the ICU who have already started opioid treatment within the last 72 hours.
This study tests whether a low-dose of ketamine (a pain medicine) can help children and young adults with sickle cell disease who are in a pain crisis. It aims to provide better pain relief while avoiding some side effects of standard painkillers.
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
This trial tests whether numbing a specific area (regional anesthesia) can reduce inflammation and pain during a sickle cell pain crisis. It may offer a new way to manage severe pain without strong medications.
Hear when a new Vaso-occlusive Crisis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.