Combination therapy for unresectable bile duct cancer
Part of Cancer clinical trials.
This trial tests a combination of three treatments—a liver-directed chemotherapy infusion (HAIC), a targeted therapy pill (lenvatinib), and an immunotherapy (pucotenlimab)—to try to shrink bile duct cancers that cannot be surgically removed. The goal is to make the cancer surgically removable or to control it for as long as possible.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with a specific type of bile duct cancer called intrahepatic cholangiocarcinoma.
- You have not received any prior systemic (whole-body) cancer treatment for this cancer.
- Your tumors are not removable by surgery, or surgery is not safe for you.
- You are at least 18 years old and your daily activities are not severely limited by the cancer.
- You have at least one tumor that can be measured on a scan, and your liver and kidney function are adequate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of a targeted drug (lenvatinib), an immunotherapy (PD-1 inhibitor), and chemotherapy given directly into the liver's blood supply for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer that starts in the liver). The goal is to see if this combination can shrink tumors or slow the cancer's growth.
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