Olanzapine for opioid misuse in cancer pain
Treatments studied
Part of Mental health clinical trials.
This study tests if a medication called olanzapine can help reduce cravings and misuse of opioid pain medicines in people with cancer pain. You would take olanzapine or a placebo daily for a few weeks while continuing your usual care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have pain from cancer and take opioids for it (for at least 7 days)
- You have used opioids in the past week
- You show signs of misusing your opioid medicine (a short questionnaire will check this)
- You are not currently taking antipsychotic medication or have certain serious psychiatric conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether the drug olanzapine can help improve appetite and reduce weight loss in people with advanced cancer who are not currently receiving chemotherapy or other anti-cancer treatment. It may be an option if you have lost weight and have little appetite.
This Phase 2 trial tests whether olanzapine can help people with advanced cancer who are losing weight and not eating enough. It looks for improvements in appetite and weight while you receive your first-line palliative cancer treatment.
This study tests whether the combination of olanzapine and metoclopramide can prevent nausea and vomiting caused by strong painkillers (opioids) in people with advanced cancer. If you are starting a strong opioid for pain and have not had nausea or vomiting recently, this study may be for you.
This trial tests whether a medication called olanzapine can help reduce nausea and loss of appetite in patients receiving chemotherapy before surgery for stomach cancer. The goal is to help you feel better and maintain nutrition during your cancer treatment.
This study tests whether olanzapine, a medication that can increase appetite, helps prevent severe appetite loss and muscle wasting in patients with ovarian or stomach cancer who are receiving chemotherapy before surgery. The goal is to help patients maintain nutrition and strength during treatment.
This study tests whether a medicine called olanzapine can improve survival in people with advanced cancers of the upper digestive system or lungs. Olanzapine may help with appetite and weight, which are common problems in these cancers.
Hear when a new Misuse, Opioid trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.