Targeted therapy for BRAF V600E mutated colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests if combining three targeted drugs (cetuximab, encorafenib, and binimetinib) before surgery can shrink or control cancer in people with a specific BRAF V600E mutation and a stable (MSS) tumor. It focuses on colorectal cancer that is either already able to be removed or could become removable with treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- 18 years or older
- Colorectal cancer with a BRAF V600E mutation and stable (MSS) tumor type
- Cancer is advanced but may be removable with surgery or could become removable
- Good overall health (able to do daily activities) and adequate organ function
- No prior treatment with a BRAF or MEK inhibitor
- No active brain metastases or serious heart conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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