L-methylfolate for treatment-resistant anxiety
Part of Mental health clinical trials.
This study tests whether adding L-methylfolate (a form of vitamin B9) to your current antidepressant can help with generalized anxiety disorder that has not responded to other treatments. It is for adults who are already on a stable dose of an SSRI or SNRI medication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have been taking a stable dose of an SSRI or SNRI antidepressant for at least 8 weeks.
- You have tried at least two different anxiety medications (each for at least 8 weeks) that did not work.
- You do not have severe depression, current suicidal thoughts, or other serious mental health conditions like bipolar disorder, schizophrenia, OCD, or substance use disorder.
- You do not use cannabis, other drugs, or drink more than 3 alcoholic drinks per week.
- You are not taking any vitamins or supplements that might affect your mood or anxiety.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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