RM-718 for obesity from hypothalamus injury or Prader-Willi syndrome
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests a new medicine called RM-718 for people with severe obesity linked to a specific brain pathway (MC4R). It may help if your obesity is due to a brain injury or tumor affecting the hypothalamus, or if you have Prader-Willi syndrome.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 12 to 65 years old and have obesity caused by a brain injury affecting the hypothalamus (like a craniopharyngioma tumor) or have Prader-Willi syndrome
- You have a body mass index (BMI) of 30 or higher (for adults) or a BMI at or above the 95th percentile for your age and sex (for children 12 to 17)
- You have not had significant weight loss in the last 3 months and are not taking other weight-loss medications
- You are medically stable and do not have serious psychiatric illness, active cancer, or severe lung, heart, or kidney disease
- You agree to use effective contraception if you are able to become pregnant or father a child
- You have not had bariatric surgery in the last 2 years (or 6 months for Prader-Willi) and are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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